Efficacy and safety of empagliflozin added to existing antidiabetes treatment in patients with type 2 diabetes and chronic kidney disease: a randomised, double-blind, placebo-controlled trial. The United States National Library of Medicine (NLM) at the National Institutes of Health maintain the database as part of the Entrez system of information retrieval.. From 1971 to 1997, online access to the MEDLINE database had been primarily through institutional …

Sep-Oct 2015;11(5):393-403. doi: 10.5055/jom.2015.0289.

Rådholm K, Figtree G, Perkovic V et al (2018) Canagliflozin and heart failure in type 2 … PMID: 26535967; DOI: … Hereon we summarize the findings of all CVOTs started after the 2008 FDA guideline published to date, namely the SAVOR-TIMI, TECOS, ELIXA, EXAMINE, EMPA-REG OUTCOME, LEADER and SUSTAIN-6 trials [44–52]. Its prevalence is increasing because of ageing of the population and improved treatment of acute cardiovascular events, despite the efficacy of many therapies for patients with heart failure with reduced ejection fraction, such as angiotensin converting enzyme (ACE) inhibitors, angiotensin receptor … BMJ Leader submissions are predominantly unsolicited, all articles submitted are subject to peer review. EUPHRATES (Evaluating the Use of Polymyxin B Hemoperfusion in a Randomized controlled trial of Adults Treated for Endotoxemia and Septic shock) is a theragnostic trial (matching blood measurement to treatment capability) of PMX hemoperfusion in patients with septic shock and confirmed endotoxemia as measured by the endotoxin activity assay (EAA).
N Engl J Med. The safety profile of liraglutide in this trial was consistent with prior clinical experience in type 2 diabetes 12 and weight management trials. 2016 Nov 10;375(19):1834-1844. doi: 10.1056/NEJMoa1607141.

Asymptomatic, dose-independent increases in amylase and lipase activity, which returned to baseline levels on treatment cessation, were observed with liraglutide. Evidence … Search in PubMed Search in NLM Catalog Add to Search . Free article Show details N Engl J Med Actions. Despite the focus on high-risk patients (a requirement for CVOT design), which poses a problem for extrapolation of results to the general patient population, the criteria for patient selection varied … No cases of pancreatitis were reported. Search in PubMed Search in NLM Catalog Add to Search . (2014). The journal operates single blind peer review whereby the names of the reviewers are hidden from the author; usually two external reviewer reports are obtained before an Original research or Review article is accepted for publication. PubMed; Google Scholar; 5. Fitchett D, Zinman B, Wanner C et al (2016) Heart failure outcomes with empagliflozin in patients with type 2 diabetes at high cardiovascular risk: results of the EMPA-REG OUTCOME® trial. 4 Therapeutic Area Lead, Pain, Janssen Scientific Affairs, LLC, Raritan, New Jersey (affiliation at the time of this work).

PubMed is a free search engine accessing primarily the MEDLINE database of references and abstracts on life sciences and biomedical topics. Article; PubMed; PubMed Central; CAS; Google Scholar; 6. 21-25 No new safety concerns were identified.

2016. 10.1002/jbmr.3063 - DOI - PubMed Barnett A., Mithal A., Manassie J.


Epub 2016 Sep 15. Semaglutide and Cardiovascular Outcomes in Patients With Type 2 Diabetes Steven P Marso et al. EUPHRATES is a pivotal regulatory trial that is … Eur Heart J 37:1526–1534 . Heart failure is common in adults, accounting for substantial morbidity and mortality worldwide. Randomized Controlled Trial.

Articles authored by a member of a journal’s editorial team are independently …

32 1072–1081.

Compound Development Team Leader, Pain Strategy Deputy Leader, Janssen Research & Development, LLC, Raritan, New Jersey. Res.


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